Inhibition of androgen and oestrogen production by clomiphene citrate in avian theca cells
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چکیده
منابع مشابه
Oestradiol feedback stimulation of androgen biosynthesis by human theca cells.
This study analysed the effect of oestradiol on basal and LH-stimulated production of androstenedione and progesterone by human theca cells in monolayer culture. Incubations were carried out for either 2 days (seven experiments) or 4 days (four experiments), in the presence or absence of luteinizing hormone (LH), oestradiol (10(-9)-10(-6) M) or inhibin. Medium collected at 48 and 96 h was store...
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Ovary is a dynamic organ and generates excess amount of reactive oxygen species (ROS) during follicular growth, development, maturation and ovulation [1]. The increased level of ROS is scavenged by antioxidant systems [2]. A moderate increase of ROS could be beneficial for oocyte meiotic maturation and reproductive outcome [3-5]. Overproduction of ROS or depletion of enzymatic antioxidant syste...
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BACKGROUND Theca cells play an important role in controlling ovarian steroidogenesis by providing aromatizable androgens for granulosa cell estrogen biosynthesis. Although it is well established that the steroidogenic activity of theca cells is mainly regulated by LH, the intracellular signal transduction mechanisms that regulate thecal proliferation and/or steroidogenesis remain obscure. In th...
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Clomiphene citrate is a white to pale yellow, essentially odorless, crystalline powder. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether. CLOMID is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. Each white scored tablet contains 50 m...
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I A T p d m c vulatory dysfunction is one of the most common causes of eproductive failure in sub-fertile and infertile couples. In the bsence of other significant infertility factors, successful vulation induction often will restore normal fertility. Cloiphene citrate (CC) is the best initial treatment for the large ajority of anovulatory infertile women. The first clinical rial of CC therapy ...
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ژورنال
عنوان ژورنال: Reproduction
سال: 1986
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0780541